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Technical University of Munich

Reaction engineering analysis of gas fermentation with Clostridium aceticum

Alexander Mayer, doctoral thesis Technical University of Munich, 2018

Clostridium aceticum converts syngas to acetate. Reaction engineering analysis performed in fully controlled stirred-tank bioreactors revealed a strong carbon monoxide (CO) inhibition and elucidated important physiological characteristics of this acetogenic microorganism converting syngas components. Despite the strong CO inhibition kinetics, syngas conversion with increased CO concentrations was enabled by adequate process control in a continuously operated membrane bioreactor.

Publications

  • Riegler P, Chrusciel T, Mayer A, Doll K, Weuster Botz D (2019): Reversible retrofitting of a stirred-tank bioreactor for gas-lift operation to perform syngas fermentation studies. Biochem Eng J 141: 89-101.
  • Mayer A, Schädler T, Trunz S, Stelzer T, Weuster-Botz D (2018): Carbon monoxide conversion with Clostridium aceticum. Biotechnol Bioeng 115: 2740–2750.
  • Mayer A, Weuster-Botz D (2017): Reaction engineering analysis of the autotrophic energy metabolism of Clostridium aceticum. FEMS Microbiol Lett 364: fnx219.
  • Kantzow C, Mayer A, Weuster-Botz D (2015): Continuous gas fermentation by Acetobacterium woodii in a submerged membrane reactor with full cell retention. J Biotechnol 212: 11-18.
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